Purpose : The purpose of this study is to investigate the impact of health care managers' job satisfaction and self-efficacy on their professional quality of life. Methods : The subjects of research and analysis are 189 health managers working throughout the country. The data collection was conducted using Google forms from May 1 to May 30, 2023. The data analysis was performed using t-test, ANOVA, correlation analysis, and multiple regression analysis using SPSS/WIN 23.0. Results : Factors affecting compassion satisfaction in the quality of professional life were job satisfaction(t=9.47, p=<.001) and self-efficacy(t=7.19, p=<.001)(F=49.12, p=<.001). Compassion fatigue in professional quality of life was expressed as job satisfaction(t=-5.71, p=<.001) and self-efficacy(t=-3.83, p=<.001)(F=25.30, p=<.001). Conclusion : In conclusion, when health managers' job satisfaction and self-efficacy are high, compassion satisfaction, a positive aspect of professional quality of life, increases, and compassion fatigue, a negative aspect, decreases.